Axonal mRNA transport and translation at a glance
Abstract
Localization and translation of mRNAs within different subcellular domains provides an important mechanism to spatially and temporally introduce new proteins in polarized cells. Neurons make use of this localized protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although the first evidence for protein synthesis in axons dates back to 1960s, improved methodologies, including the ability to isolate axons to purity, highly sensitive RNA detection methods and imaging approaches, have shed new light on the complexity of the transcriptome of the axon and how it is regulated. Moreover, these efforts are now uncovering new roles for locally synthesized proteins in neurological diseases and injury responses. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of how axonal mRNA transport and translation are regulated, and discuss their emerging links to neurological disorders and neural repair.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 13, 2018
- Source ID
- 10.1242/jcs.196808
Entities
People
- Deanna S Smith
- Jeffery L Twiss
- Nora Perrone-Bizzozero
- Pabitra K Sahoo
Organizations
- Adelson Foundation
- National Institutes of Health
- National Science Foundation
- United States Department of Defense
- University of New Mexico
- University of South Carolina