Recent advances in treating oesophageal cancer
Abstract
Esophageal cancer (EC) is an aggressive malignancy with an increasing incidence and a poor prognosis. EC is histologically divided into two major categories: adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). EAC and ESCC are molecularly different and therefore treatments should reflect the respective histological subtype. Combined modality therapy is needed for localized EC. When EC is advanced (stage 4), systemic therapy is the mainstay treatment for palliation. For localized EC, several strategies are considered standard, and more trials are necessary to determine a unified and more effective approach. The management for advanced EC is slowly evolving as immunotherapy is showing some promise for ESCC, but more data from ongoing studies are anticipated. Treatment advances will be based on high-definition genomic investigation of individual tumors. Herein, we review the contemporary trends in diagnosing and treating EAC and ESCC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2020
- Source ID
- 10.12688/f1000research.22926.1
Entities
People
- Hideo Baba
- Jaffer A. Ajani
- Jane E. Rogers
- Kazuto Harada
- Kohei Yamashita
- Masaaki Iwatsuki
Organizations
- Japan Society for the Promotion of Science
- National Cancer Institute
- The University of Texas MD Anderson Cancer Center
- United States Department of Defense