Quantum-enhanced stimulated Brillouin scattering spectroscopy and imaging
Abstract
Brillouin microscopy is an emerging label-free imaging technique used to assess local viscoelastic properties. Quantum-enhanced stimulated Brillouin scattering is demonstrated using low power continuous-wave lasers at 795 nm. A signal-to-noise ratio enhancement of 3.4 dB is reported by using two-mode intensity-difference squeezed light generated with the four-wave mixing process in atomic rubidium vapor. The low optical power and the excitation wavelengths in the water transparency window have the potential to provide a powerful bio-imaging technique for probing mechanical properties of biological samples prone to phototoxicity and thermal effects. The performance enhancement affordable through the use of quantum light may pave the way for significantly improved sensitivity that cannot be achieved classically. The proposed method for utilizing squeezed light for enhanced stimulated Brillouin scattering can be easily adapted for both spectroscopic and imaging applications in biology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 18, 2022
- Source ID
- 10.1364/optica.467635
Entities
People
- G. S. Agarwal
- Lin Fu
- Tian Li
- Vladislav V Yakovlev
- Xinghua Liu
Organizations
- Air Force Office of Scientific Research
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute
- National Institute of General Medical Sciences
- National Science Foundation
- Robert A. Welch Foundation
- Texas A&M University
- United States Army Medical Command
- University of Tennessee at Chattanooga