Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells
Abstract
The mosquito Aedes aegypti is a major vector for the arthropod-borne viruses (arboviruses) chikungunya, dengue, yellow fever and Zika viruses. Vector immune responses pose a major barrier to arboviral transmission, and transgenic insects with altered immunity have been proposed as tools for reducing the global public health impact of arboviral diseases. However, a better understanding of virus-immune interactions is needed to progress the development of such transgenic insects. Although the NF-κB-regulated Toll and ‘immunodeficiency’ (Imd) pathways are increasingly thought to be antiviral, relevant pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs) remain poorly characterised in A. aegypti.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 16, 2021
- Source ID
- 10.1371/journal.pntd.0008524
Entities
People
- Ana Fernández-Sesma
- Andalus Ayaz
- Andrew D Davidson
- Kevin Maringer
- Tiffany A Russell
Organizations
- Defense Advanced Research Projects Agency
- Icahn School of Medicine at Mount Sinai
- Medical Research Council
- National Institute of Allergy and Infectious Diseases
- Wellcome Trust