Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis
Abstract
Yersinia pestis is the causative agent of plague, a zoonosis associated with small mammals. Plague is a severe disease, especially in the pneumonic and septicemic forms, where fatality rates approach 100% if left untreated. The bacterium is primarily transmitted via flea bite or through direct contact with an infected host. The 2017 plague outbreak in Madagascar resulted in more than 2,400 cases and was highlighted by an increased number of pneumonic infections. Standard diagnostics for plague include laboratory-based assays such as bacterial culture and serology, which are inadequate for administering immediate patient care for pneumonic and septicemic plague.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 23, 2022
- Source ID
- 10.1371/journal.pntd.0010287
Entities
People
- Brian Wade
- Cameron J. Creek
- Chonnikarn Chokapirat
- Chris Lovejoy
- Dana E. Reed
- David Paul AuCoin
- Derrick Hau
- Emily E Hannah
- Garett F. Cecchini
- Haley L. Demers
- Heather R Green
- Jose Arias-Umana
- Kathryn J. Pflughoeft
- Marcellene A. Gates-hollingsworth
- Megan E. Mclarty
- Peter N. Thorkildson
- Sujata G. Pandit
- Teerapat Nualnoi
Organizations
- Defense Threat Reduction Agency
- United States Naval Research Laboratory