NHP BurkPx: A multiplex serodiagnostic bead assay to monitor Burkholderia pseudomallei exposures in non-human primates
Abstract
Melioidosis is a disease caused by the bacterium Burkholderia pseudomallei, infecting humans and non-human primates (NHP) through contaminated soil or water. World-wide there are an estimated 165,000 human melioidosis cases each year, but recordings of NHP cases are sporadic. Clinical detection of melioidosis in humans is primarily by culturing B. pseudomallei, and there are no standardized detection protocols for NHP. NHP are an important animal model for melioidosis research including clinical trials and development of biodefense countermeasures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 08, 2023
- Source ID
- 10.1371/journal.pntd.0011067
Entities
People
- Austin B Shannon
- Christopher Allender
- Daniel Sanford
- Derek Sonderegger
- Elizabeth S. Didier
- Erik Settles
- Fernando P Monroy
- Heidie Hornstra
- Jinhee Yi
- Kathrine Phillippi-falkenstein
- Kimberly R. Celona
- Mary B. Barnes
- Paul Keim
- Rudolf P. Bohm
Organizations
- Defense Threat Reduction Agency
- National Institutes of Health