Circulating whole genome miRNA expression corresponds to progressive right ventricle enlargement and systolic dysfunction in adults with tetralogy of Fallot
Abstract
The adult congenital heart disease population with repaired tetralogy of Fallot (TOF) is subject to chronic volume and pressure loading leading to a 40% probability of right ventricular (RV) failure by the 3rd decade of life. We sought to identify a non-invasive signature of adverse RV remodeling using peripheral blood microRNA (miRNA) profiling to better understand the mechanisms of RV failure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 11, 2020
- Source ID
- 10.1371/journal.pone.0241476
Entities
People
- Anne Taylor
- Brittany Navarre
- Chad S Weldy
- Dong-qing Hu
- Myriam Amsallem
- Rajesh Punn
- Saad Ali Syed
- Sushma Reddy
- Xuhuai Ji
Organizations
- American Heart Association
- National Heart, Lung, and Blood Institute
- United States Department of Defense