Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation
Abstract
Adult elastic cartilage has limited repair capacity. MRL/MpJ (MRL) mice, by contrast, are capable of spontaneously healing ear punctures. This study was undertaken to characterize microbiome differences between healer and non-healer mice and to evaluate whether this healing phenotype can be transferred via gut microbiome transplantation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2021
- Source ID
- 10.1371/journal.pone.0248322
Entities
People
- Alexander Rivas
- Cassandra Sturdy
- Cassandra Velasco
- Christopher M. Dunn
- Jake Martin
- Jeffrey Mcnaughton
- Matlock Jeffries
- Vladislav Izda
Organizations
- Congressionally Directed Medical Research Programs
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of General Medical Sciences
- Oklahoma Center for the Advancement of Science and Technology
- Presbyterian Health Foundation