Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury
Abstract
Muscle biopsies are the gold standard to assess mitochondrial respiration; however, biopsies are not always a feasible approach in persons with spinal cord injury (SCI). Peripheral blood mononuclear cells (PBMCs) and near-infrared spectroscopy (NIRS) may alternatively be predictive of mitochondrial respiration. The purpose of the study was to evaluate whether mitochondrial respiration of PBMCs and NIRS are predictive of respiration of permeabilized muscle fibers after SCI.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 11, 2022
- Source ID
- 10.1371/journal.pone.0265141
Entities
People
- Ashraf S Gorgey
- Edward J. Lesnefsky
- Jeannie Rivers
- Matthew E Holman
- Qun Chen
- Raymond E. Lai
Organizations
- United States Department of Defense