Development, refinement, and characterization of a nonhuman primate critical care environment
Abstract
Systemic inflammatory response remains a poorly understood cause of morbidity and mortality after traumatic injury. Recent nonhuman primate (NHP) trauma models have been used to characterize the systemic response to trauma, but none have incorporated a critical care phase without the use of general anesthesia. We describe the development of a prolonged critical care environment with sedation and ventilation support, and also report corresponding NHP biologic and inflammatory markers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 17, 2023
- Source ID
- 10.1371/journal.pone.0281548
Entities
People
- Crystal Leonhardt
- Daniel S Chertow
- Eric A. Elster
- John A. Mares
- Joseph D Bozzay
- Matthew J. Bradley
- Patrick F Walker
- Rex E. Atwood
- Robert W. Despain
- William J. Parker
Organizations
- Naval Medical Research Center