The inflammatory response of human pancreatic cancer samples compared to normal controls
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options. PDAC growth has been linked to alterations in the pancreas microbiome, which could include the presence of the fungus Malassezia. We used RNA-sequencing to compare 14 matched tumor and normal (tumor adjacent) pancreatic cancer samples and found Malassezia RNA in both the PDAC and normal tissues. Although the presence of Malassezia was not correlated with tumor growth, a set of immune- and inflammatory-related genes were up-regulated in the PDAC compared to the normal samples, suggesting that they are involved in tumor progression. Gene set enrichment analysis suggests that activation of the complement cascade pathway and inflammation could be involved in pro PDAC growth.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2023
- Source ID
- 10.1371/journal.pone.0284232
Entities
People
- Cathleen Martinez
- Ian Rabinowitz
- Joshua A. Hanson
- Kathryn J. Brayer
- Scott A. Ness
- Shashank Cingam
Organizations
- Defense Threat Reduction Agency
- Health Sciences Center, University of New Mexico
- New Mexico Space Grant Consortium
- Translational Genomics Research Institute