Quantification of Fragments of Human Serum Inter-α-Trypsin Inhibitor Heavy Chain 4 by a Surface-Enhanced Laser Desorption/Ionization-Based Immunoassay

Abstract

Background: Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-α-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 01, 2006
Source ID
10.1373/clinchem.2005.065722

Entities

People

  • C. Nicole Rosenzweig
  • Daniel W. Chan
  • Eric T Fung
  • Jin H Song
  • Lori J. Sokoll
  • Manisha Patel
  • Michael Goggins
  • Nam-ho Choi-miura
  • Yee Chan-li
  • Zhen Zhang

Organizations

  • Johns Hopkins School of Medicine
  • National Cancer Institute
  • National Institutes of Health
  • Showa Medical University
  • United States Department of Defense

Tags

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry

Technology Areas

  • Directed Energy