Very Low PSA Concentrations and Deletions of the KLK3 Gene
Abstract
Prostate-specific antigen (PSA), a widely used biomarker for prostate cancer (PCa), is encoded by a kallikrein gene (KLK3, kallikrein-related peptidase 3). Serum PSA concentrations vary in the population, with PCa patients generally showing higher PSA concentrations than control individuals, although a small proportion of individuals in the population display very low PSA concentrations. We hypothesized that very low PSA concentrations might reflect gene-inactivating mutations in KLK3 that lead to abnormally reduced gene expression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2013
- Source ID
- 10.1373/clinchem.2012.192815
Entities
People
- Angela Cox
- David E. Neal
- Freddie C. Hamdy
- Gemma Marsden
- Ian Nm Day
- J. Athene Lane
- Jenny L Donovan
- Khalid K Alharbi
- Kimberley Burrows
- Michael S. Davis
- Osama A Al-ghamdi
- Philip Ai Guthrie
- Santiago Rodriguez
Organizations
- Cancer Research UK
- King Saud University
- Medical Research Council
- National Cancer Research Institute
- National Institute for Health and Care Research
- United States Department of Defense
- University of Bristol
- University of Cambridge
- University of Oxford
- University of Sheffield
- Yorkshire Cancer Research