Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models
Abstract
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 09, 2022
- Source ID
- 10.1523/jneurosci.1136-22.2022
Entities
People
- Andrew Macaskill
- Candela Sánchez-bellot
- David A. Kupferschmidt
- Hugo A. Tejeda
- Héctor E. Yarur
- Kirstie A. Cummings
- Max E. Joffe
- Ruchi Malik
Organizations
- Brain & Behavior Research Foundation
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute on Alcohol Abuse and Alcoholism
- United States Department of Defense
- Wellcome