The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer
Abstract
A better assessment of individualized prostate cancer (PrCa) risk is needed to improve screening. The use of the prostate-specific antigen (PSA) level for screening in the general population has limitations and is not currently advocated. Approximately 100 common single nucleotide polymorphisms (SNPs) have been identified that are associated with the risk of developing PrCa. The PROFILE pilot study explored the feasibility of using SNP profiling in men with a family history (FH) of PrCa to investigate the probability of detecting PrCa at prostate biopsy (PB). The primary aim of this pilot study was to determine the safety and feasibility of PrCa screening using transrectal ultrasound-guided PB with or without diffusion-weighted magnetic resonance imaging (DW-MRI) in men with a FH. A secondary aim was to evaluate the potential use of SNP profiling as a screening tool in this population.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 05, 2016
- Source ID
- 10.1634/theoncologist.2015-0336
Entities
People
- Antonis C. Antoniou
- Chee Goh
- Christos Mikropoulos
- David E. Neal
- Diana Keating
- Edward Saunders
- Elena Castro
- Elizabeth C. Page
- Elizabeth K. Bancroft
- Freddie C. Hamdy
- Nandita Desouza
- Naomi Livni
- Natalie Taylor
- Nigel Borley
- Pardeep Kumar
- Rosalind Eeles
- Sibel Saya
- Stephen Hazell
- The Profile Study Steering Committee
- Tokhir Dadaev
- Zsofia Kote-jarai
Organizations
- American Society of Clinical Oncology
- Canadian Institutes of Health Research
- Cancer Foundation
- Cancer Research UK
- European Society for Medical Oncology
- Institute of Cancer Research
- National Institutes of Health
- Ovarian Cancer Research Alliance
- The Breast Cancer Research Foundation
- The Royal Marsden NHS Foundation Trust
- United States Department of Defense
- University of Cambridge
- University of Oxford