Murine Epsins Play an Integral Role in Podocyte Function
Abstract
When podocytes are injured, foot processes efface and detach, leading to severe proteinuria. Endocytic trafficking maintains the integrity of this crucial glomerular interface. Epsins, a family of membrane proteins, assist in the endocytosis and also take part in cell signaling. Mice that have lost podocyte-associated epsins develop proteinuria and kidney failure, due to diminished activity of the transcription factor serum response factor (SRF), which reduces cell division control protein 42 homolog activation and β 1 integrin expression. Podocyte-specific Srf knockout mice also demonstrate proteinuria and kidney failure. These findings suggest that, in podocytes, epsins are required to coordinate a proper signaling platform, beyond their known endocytic properties.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 13, 2020
- Source ID
- 10.1681/asn.2020050691
Entities
People
- Christopher E. Pedigo
- Eike Schwartze
- Elizabeth Cross
- Jee Won Shin
- Karen Ebenezer
- Kazunori Inoue
- Marwin Groener
- Shuta Ishibe
- Wei Li
- Xuefei Tian
- Ying Wang
- Zhen Wang
Organizations
- Beijing University of Chinese Medicine
- China Scholarship Council
- National Institutes of Health
- United States Department of Defense
- Yale School of Medicine
- Yale University