Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease
Abstract
Antiglomerular basement membrane (GBM) disease clinically presents as rapidly progressive GN, often accompanied by pulmonary hemorrhage. The autoantibodies that mediate the disease typically recognize cryptic epitopes within α345(IV) collagen in the glomerular and alveolar basement membranes. Laminin-521 is another major autoantigen that autoantibodies in anti-GBM disease target. These autoantibodies were detected in 51.5% of patients with both kidney and lung involvement of anti-GBM disease, compared with 23.5% of patients with isolated kidney disease. Seropositivity for antilaminin autoantibodies was significantly associated with lung hemorrhage, hemoptysis, and smoking. Antilaminin autoantibodies may contribute to lung injury in anti-GBM disease by increasing the amount of IgG bound to the alveolar basement membrane.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2021
- Source ID
- 10.1681/asn.2020101431
Entities
People
- Cong-rong Shen
- Dorin-Bogdan Borza
- Florina Olaru
- Ming-Hui Zhao
- Wentian Luo
- Xiao-yu Jia
- Zhao Cui
Organizations
- Chinese Academy of Medical Sciences
- Meharry Medical College
- National Institute on Minority Health and Health Disparities
- National Natural Science Foundation of China
- Peking University
- Peking-Tsinghua Center for Life Sciences
- United States Department of Defense
- Vanderbilt University Medical Center