GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus
Abstract
HIV-associated nephropathy (HIVAN) is a well-recognized complication of HIV infection that manifests with collapsing FSGS, tubular microcysts, interstitial fibrosis, and inflammation. Genetic predisposition to human HIVAN has been associated with variants of APOL1; however, the APOL1 risk alleles are incompletely penetrant, and it is very likely there are other common and rare risk genetic factors. Studying a validated mouse model of HIVAN, we found large differences in nephropathy susceptibility and severity among inbred strains. A genome-wide association study identified a major locus on Chr. 13 and suggests Ssbp2 as the candidate gene conferring susceptibility to HIVAN in the mouse. Identification of novel genes associated with HIVAN and other virally mediated glomerulopathies should foster the design of innovative therapeutics and better patient management.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1681/asn.2021040543
Entities
People
- Ali G. Gharavi
- Anna Mo
- Dina F. Ahram
- Judy Liang
- Kelsey O. Stevens
- Lalitha Nagarajan
- Mihai Gagea
- Natalia Demaria
- Nicholas J. Steers
- Simone Sanna-cherchi
- Tze Y. Lim
- Vivette D. D’agati
- Wan Yee Lam
- Yask Gupta
Organizations
- Columbia University
- United States Department of Defense
- University of Texas at Austin