Extracellular Vesicles as Therapeutics for Brain Injury and Disease
Abstract
Extracellular vesicles (EVs) are gaining tremendous importance in comprehending central nervous system (CNS) function and treating neurological disorders because of their role in intercellular communication and reparative processes, and suitability as drug delivery vehicles. Since EVs have lipid membranes, they cross the blood-brain barrier easily and communicate with target neurons and glia even deep inside the brain. EVs from various sources have been isolated, characterized, and tailored for promoting beneficial effects in conditions, such as brain injury and disease. Particularly, EVs isolated from mesenchymal stem cells and neural stem cells have shown promise for alleviating brain dysfunction after injury or disease. Such properties of stem cell-derived EVs have great importance for clinical applications, as EV therapy can avoid several concerns typically associated with cell therapy. This minireview confers the competence of EVs for improving brain function by modulating CNS injury and disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 19, 2019
- Source ID
- 10.2174/1381612825666191014164950
Entities
People
- Ashok K. Shetty
- Dinesh Upadhya
Organizations
- Manipal Academy of Higher Education
- National Institute of Neurological Disorders and Stroke
- Science and Engineering Research Board
- Texas A&M Health Science Center
- United States Department of Defense