Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal
Abstract
Aim: Explore the potential of urine microRNAs as biomarkers that may reflect the biological responses to pure metals embedded in skeletal muscle over time. Materials & methods: We tested a panel of military-relevant metals embedded in the gastrocnemius muscles of 3-month-old, male, Sprague–Dawley rats (n = 8/group) for a duration of 1, 3, 6 and 12 months, and performed small RNA-sequencing on the urine samples. Results: Results provide potential tissue targets affected by metal exposure and a list of unique or common urine microRNA biomarkers indicative of exposure to various metals, highlighting a complex systemic response. Conclusion: We have identified a panel of miRNAs as potential urine biomarkers to reflect the complex systemic response to embedded metal exposure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2021
- Source ID
- 10.2217/bmm-2021-0120
Entities
People
- Alexander P. Alimov
- Charlotte Peterson
- Ivan José Vechetti
- Jessica F Hoffman
- Joanna M Gaitens
- John F. Kalinich
- John J. Mccarthy
- Melissa A. Mcdiarmid
- Stella E Hines
- Vernieda B. Vergara
- Yuan Wen
Organizations
- Congressionally Directed Medical Research Programs
- Uniformed Services University of the Health Sciences
- United States Department of Veterans Affairs
- University of Kentucky
- University of Maryland School of Medicine
- University of Nebraska–Lincoln