Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery
Abstract
Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. Methods: This study fabricated novel trifunctional MNPs of Fe3O4@PLA-PEG for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity ( r2 = 364.75 mM-1s-1). The in vivo study confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential for drug release, cancer treatment monitoring and therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2022
- Source ID
- 10.2217/nnm-2022-0070
Entities
People
- Do Hung Manh
- Ha Phuong Thu
- Javier Alonso Masa
- Ju Qiao
- Lam Khanh
- Manh-Huong Phan
- N.X. Phuc
- Nguyen Dac Tu
- Nguyen TK Thanh
- Nhung Thi My Hoang
- Phan Quoc Thong
- Phạm Hồng Nam
- Srinivas Sridhar
- Thi Thu Huong Le
Organizations
- Conroe ISD Academy of Science and Technology
- Duy Tan University
- Engineering and Physical Sciences Research Council
- Hanoi University of Science
- Northeastern University
- University College London
- University of Cantabria
- University of Khanh Hoa
- University of South Florida