Mechanical, topographical and chemical cues combined with physical therapy for peripheral nerve injuries
Abstract
Aim: The aim of this paper is to evaluate biomaterial cues combined with physical therapy (PT) on functional recovery in a rat sciatic nerve injury model. Materials & methods: Nerve growth conduits were filled with longitudinally aligned hyaluronic acid fibers and microspheres containing neurotrophic factor (growth factor [GF]). All animals received behavior and functional testing throughout the study, which concluded with measurement of compound muscle action potentials and contractile force of the gastrocnemius muscle. Results & conclusion: Including GF improved recovery of gross motor function and increased sensory pain sensation. During the 4 weeks that animals participated in PT, these groups showed higher static sciatic index scores. Including GF and PT has the potential to improve clinical outcomes following peripheral nerve injury.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2020
- Source ID
- 10.2217/rme-2020-0059
Entities
People
- Anthony Mora
- Assadollah Mazhari
- Chaoyang Chen
- Elizabeth A Mays
- Harini G Sundararaghavan
- Jean Peduzzi
- Monica Prasad
- Tonya J Whitehead
Organizations
- United States Department of Defense
- Wayne State University