DYT-TOR1A genotype alters extracellular vesicle composition in murine cell model and shows potential for biomarker discovery
Abstract
Introduction: Biomarkers that can be used to identify patient subgroups with shared pathophysiology and/or that can be used as pharmacodynamic readouts of disease state are valuable assets for successful clinical trial design. In translational research for brain diseases, extracellular vesicles (EVs) have become a high-priority target for biomarker discovery because of their ubiquity in peripheral biofluids and potential to indicate brain state.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 16, 2023
- Source ID
- 10.3389/dyst.2023.11053
Entities
People
- Connor S. King
- Erik J. Soderblom
- Nicole Calakos
- Zachary F. Caffall
Organizations
- Congressionally Directed Medical Research Programs
- Neurocrine Biosciences