Injured nerves respond favorably to an integrated tension- and conduit-based regenerative strategy
Abstract
Introduction: Numerous synthetic, hybrid, and biological grafts and conduits have been deployed to facilitate axonal regeneration across peripheral nerve gaps. Though some strategies have showed promise, larger gaps continue to be an unsolved clinical challenge. Recent evidence suggests that tension-based strategies offer a promising alternative approach to nerve repair. However, whether and to what degree severed peripheral nerves tolerate and accommodate tension, especially in the critical early stages of intervention, is less clear.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 02, 2023
- Source ID
- 10.3389/fbiom.2023.1041018
Entities
People
- Elisabeth Orozco
- Jae Jun Nam
- Kenneth Vaz
- Richard M. Lovering
- Sameer B Shah
- Ting-hsien Chuang
Organizations
- National Science Foundation
- United States Department of Defense