Interleukin-6 Elevation Is a Key Pathogenic Factor Underlying COVID-19-Associated Heart Rate-Corrected QT Interval Prolongation
Abstract
Heart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory response characterizing the disease, specifically interleukin-6 (IL-6) increase, may have an important role, possibly via direct effects on cardiac electrophysiology. The aim of this study was to dissect the short-term discrete impact of IL-6 elevation on QTc in patients with severe COVID-19 infection and explore the underlying mechanisms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 19, 2022
- Source ID
- 10.3389/fcvm.2022.893681
Entities
People
- Alessandra Cartocci
- Antonio D’errico
- Decoroso Verrengia
- Fabio Salvadori
- Franco Laghi-pasini
- Gabriele Cevenini
- Ke-su Chen
- Long Chen
- Maria Romana Bacarelli
- Matteo Capecchi
- Maurizio Acampa
- Mohamed Boutjdir
- Pier Leopoldo Capecchi
- Pietro Enea Lazzerini
- Riccardo Accioli
- Stefania Bisogno
- Tommaso Marzotti
- Viola Salvini
- Wen-hui Zhang
- Xiaofeng Xin
Organizations
- Office of Academic Affiliations, Department of Veterans Affairs
- United States Department of Defense