Extracellular matrix and cyclic stretch alter fetal cardiomyocyte proliferation and maturation in a rodent model of heart hypoplasia
Abstract
Birth defects, particularly those that affect development of the heart, are a leading cause of morbidity and mortality in infants and young children. Babies born with heart hypoplasia (heart hypoplasia) disorders often have a poor prognosis. It remains unclear whether cardiomyocytes from hypoplastic hearts retain the potential to recover growth, although this knowledge would be beneficial for developing therapies for heart hypoplasia disorders. The objective of this study was to determine the proliferation and maturation potential of cardiomyocytes from hypoplastic hearts and whether these behaviors are influenced by biochemical signaling from the extracellular matrix (ECM) and cyclic mechanical stretch.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 28, 2022
- Source ID
- 10.3389/fcvm.2022.993310
Entities
People
- Corin Williams
- Kelly E. Sullivan
- Lauren D. Black Iii
- Luke R. Perreault
- Matthew C. Watson
- Raymond M. Wang
- Whitney L Stoppel
Organizations
- American Heart Association
- Congressionally Directed Medical Research Programs
- National Institutes of Health
- National Science Foundation