In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries
Abstract
Donor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI). Complement is activated and deposited within solid organ grafts as a consequence of BD and has been shown to exacerbate IRI, although the role of BD and complement in VCA and the role it plays in IRI and VCA rejection has not been studied.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 29, 2021
- Source ID
- 10.3389/fimmu.2021.630581
Entities
People
- Biao Lei
- Carl Atkinson
- Logan Langerude
- M. Mahdi Sleiman
- Martin Goddard
- Paulo N. Martins
- Peng Zhu
- Qi Cheng
- Satish Nadig
- Stephen Tomlinson
- Zhenxiao Tu
Organizations
- National Institutes of Health
- United States Department of Defense