Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease
Abstract
Inflammation is a common unifying factor in experimental models of non-alcoholic fatty liver disease (NAFLD) progression. Recent evidence suggests that housing temperature-driven alterations in hepatic inflammation correlate with exacerbated hepatic steatosis, development of hepatic fibrosis, and hepatocellular damage in a model of high fat diet-driven NAFLD. However, the congruency of these findings across other, frequently employed, experimental mouse models of NAFLD has not been studied.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 17, 2023
- Source ID
- 10.3389/fimmu.2023.1095132
Entities
People
- Daniel A. Giles
- Jarren R. Oates
- Keisuke Sawada
- Maria E. Moreno-fernandez
- Michelle S.m.a. Damen
- Pablo C Alarcon
- Sara Szabo
- Senad Divanovic
- Traci E. Stankiewicz
Organizations
- American Diabetes Association
- American Heart Association
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Department of Defense