Adherent-invasive E. coli – induced specific IgA limits pathobiont localization to the epithelial niche in the gut

Abstract

Adherent-invasive E. coli (AIEC) has been identified as a pathobiont associated with Crohn’s disease (CD), that prefers to grow in inflammatory conditions. Although the colonization by AIEC is implicated in the progression of the disease and exacerbates inflammation in murine colitis models, the recognition and response of host immunity to AIEC remains elusive.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 23, 2023
Source ID
10.3389/fmicb.2023.1031997

Entities

People

  • Hidekazu Suzuki
  • Hiroko Nagao-kitamoto
  • Hitoshi Tsugawa
  • Jin Imai
  • Karl Bil Eap
  • Katsuto Hozumi
  • Kohei Sugihara
  • Masaki Yazawa
  • Masashi Matsushima
  • Masashi Ohno
  • Motoki Kaneko
  • Nicolas Barnich
  • Nobuhiko Kamada
  • Rika Tanaka
  • Sho Kitamoto
  • Takayoshi Suzuki
  • Tatehiro Kagawa
  • Yasuhiro Nishizaki

Organizations

  • Japan Society for the Promotion of Science
  • National Institutes of Health
  • United States Department of Defense

Tags

Fields of Study

  • Biology

Readers

  • Economics
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology