Image discrimination reversal learning is impaired by sleep deprivation in rats: Cognitive rigidity or fatigue?
Abstract
Insufficient sleep is pervasive worldwide, and its toll on health and safety is recapitulated in many settings. It is thus important to understand how poor sleep affects the brain and decision making. A robust literature documents the adverse effects of sleep deprivation on cognitive processes including cognitive flexibility, which is the capacity to appraise new feedback and make behavioral adjustments to respond appropriately. Animal models are often used to unravel the molecules, genes and neural circuits that are altered by sleep loss. Herein we take a translational approach to model the effects of sleep deprivation on cognitive rigidity, i.e., impaired cognitive flexibility in rats.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 17, 2022
- Source ID
- 10.3389/fnsys.2022.1052441
Entities
People
- Brian K. Strobel
- Christopher J. Davis
- Daniel O. Harvey
- Michelle Schmidt
Organizations
- Congressionally Directed Medical Research Programs