Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries
Abstract
Background: Elevations of inflammatory cytokine levels occur immediately after mild traumatic brain injury (mTBI) and can persist for years. These elevations have been associated with neuropsychological outcomes, including depression and PTSD symptoms. Sleep disorders, another common sequelae of mTBI, are independently associated with inflammation in otherwise healthy individuals. However, whether sleep and inflammation are linked in chronic mTBI has not been reported.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 27, 2022
- Source ID
- 10.3389/fphar.2021.762077
Entities
People
- Ainslee Gabriel
- Bao-xi Qu
- Chen Lai
- Christina Devoto
- Daniel I. Brooks
- J. Kent Werner
- Jackie L. Gottshall
- Jacqueline J. Leete
- Jessica M. Gill
- Josephine U. Pucci
- Kimbra Kenney
- Nora Watson
- Phorum Sheth
- Sara Mithani
- Vivian A. Guedes
Organizations
- United States Army Medical Command
- United States Department of Veterans Affairs