Mechanisms of lymphoid depletion in bowel obstruction
Abstract
Background and aims: Bowel obstruction (BO) causes not only gastrointestinal dysfunctions but also systemic responses such as sepsis, infections, and immune impairments. The mechanisms involved are not well understood. In this study, we tested the hypothesis that BO leads to lymphoid depletion in primary and peripheral lymphoid organs, which may contribute to systemic responses. We also sought to uncover mechanisms of lymphoid depletion in BO.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2022
- Source ID
- 10.3389/fphys.2022.1005088
Entities
People
- Shrilakshmi Hegde
- Xuan-Zheng Shi
- Yingzi Cong
- You-min Lin
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Department of Defense