Smooth muscle dysfunction in the pre-inflammation site in stenotic Crohn’s-like colitis: implication of mechanical stress in bowel dysfunction in gut inflammation
Abstract
Background and Aims: Gut smooth muscle dysfunctions contribute to symptoms such as abdominal cramping, diarrhea, and constipation in inflammatory bowel disease (IBD). The mechanisms for muscle dysfunctions are incompletely understood. We tested the hypothesis that mechanical stress plays a role in muscle dysfunction in a rat model of Crohn’s-like colitis where inflammatory stenosis leads to mechanical distention in the pre-inflammation site.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 14, 2023
- Source ID
- 10.3389/fphys.2023.1215900
Entities
People
- Amosy E. M’koma
- John C. Johnson
- Ke Zhang
- Ramasatyaveni Geesala
- Xuan-Zheng Shi
- You-min Lin
Organizations
- National Institutes of Health
- United States Department of Defense