Concise Review: Bioengineering of Limbal Stem Cell Niche
Abstract
The corneal epithelium is composed of nonkeratinized stratified squamous cells and has a significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the cornea as well as regeneration of the corneal epithelium. Limbal epithelial stem cells (LESCs) are located in the basal epithelial layer of the limbus and preserve this homeostasis. Proper functioning of LESCs is dependent on a specific microenvironment, known as the limbal stem cell niche (LSCN). This structure is made up of various cells, an extracellular matrix (ECM), and signaling molecules. Different etiologies may damage the LSCN, leading to limbal stem cell deficiency (LSCD), which is characterized by conjunctivalization of the cornea. In this review, we first summarize the basics of the LSCN and then focus on current and emerging bioengineering strategies for LSCN restoration to combat LSCD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 12, 2023
- Source ID
- 10.3390/bioengineering10010111
Entities
People
- Ali R Djalilian
- Kasra Cheraqpour
- Mohammad Soleimani
- Raghuram Koganti
- Seyed Mahbod Baharnoori
Organizations
- Research to Prevent Blindness
- United States Department of Defense