Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics
Abstract
Vascularized composite allotransplantation addresses injuries to complex anatomical structures such as the face, hand, and abdominal wall. Prolonged static cold storage of vascularized composite allografts (VCA) incurs damage and imposes transportation limits to their viability and availability. Tissue ischemia, the major clinical indication, is strongly correlated with negative transplantation outcomes. Machine perfusion and normothermia can extend preservation times. This perspective introduces multiplexed multi-electrode bioimpedance spectroscopy (MMBIS), an established bioanalytical method to quantify the interaction of the electrical current with tissue components, capable of measuring tissue edema, as a quantitative, noninvasive, real-time, continuous monitoring technique to provide crucially needed assessment of graft preservation efficacy and viability. MMBIS must be developed, and appropriate models explored to address the highly complex multi-tissue structures and time-temperature changes of VCA. Combined with artificial intelligence (AI), MMBIS can serve to stratify allografts for improvement in transplantation outcomes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 29, 2023
- Source ID
- 10.3390/bioengineering10040434
Entities
People
- Anthony Guiseppi-Elie
- Carolyn Ton
- Gerald Brandacher
- John R Aggas
- Renee Liu
- Sara Abasi
- Sara Salehi
- Warren L Grayson
Organizations
- Hoffmann-La Roche
- Johns Hopkins University
- Texas Engineering Experiment Station
- United States Department of Defense