35 Years of TFAM Research: Old Protein, New Puzzles
Abstract
Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 06, 2023
- Source ID
- 10.3390/biology12060823
Entities
People
- Mikhail F Alexeyev
- Natalya Kozhukhar
Organizations
- National Institutes of Health
- United States Department of Defense
- University of South Alabama