Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart
Abstract
During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular tissue. In response to injury, there is an increase in inflammation within the heart due to the influx of immune cells. Some of the most common immune cells recruited to the heart are macrophages, dendritic cells, neutrophils, and T-cells. In this review, we will discuss what is known about cardiac immune cell heterogeneity during homeostasis, how these cell populations change in response to a pathology such as myocardial infarction or pressure overload, and what stimuli are regulating these processes. In addition, we will summarize technologies used to evaluate cell heterogeneity in models of cardiovascular disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 22, 2021
- Source ID
- 10.3390/biom12010011
Entities
People
- Alexa Corker
- Amy D Bradshaw
- Kristine Y DeLeon-Pennell
- Lily S. Neff
- Philip Broughton
Organizations
- American Heart Association
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- United States Department of Defense