Regulation of Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes
Abstract
Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface that control a myriad of cellular functions despite their low abundance among phospholipids. The metabolic cycle that generates different PI species is crucial to their regulatory role, controlling membrane dynamics, vesicular trafficking, signal transduction, and other key cellular events. The synthesis of phosphatidylinositol (3,4,5)-triphosphate (PI3,4,5P3) in the cytoplamic PI3K/Akt pathway is central to the life and death of a cell. This review will focus on the emerging evidence that scaffold proteins regulate the PI3K/Akt pathway in distinct membrane structures in response to diverse stimuli, challenging the belief that the plasma membrane is the predominant site for PI3k/Akt signaling. In addition, we will discuss how PIs regulate the recruitment of specific scaffolding complexes to membrane structures to coordinate vesicle formation, fusion, and reformation during autophagy as well as a novel lysosome repair pathway.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 24, 2023
- Source ID
- 10.3390/biom13091297
Entities
People
- Narendra Thapa
- Richard A. Anderson
- Tianmu Wen
- Vincent L Cryns
Organizations
- Foundation for the National Institutes of Health
- The Breast Cancer Research Foundation
- United States Department of Defense
- University of Wisconsin–Madison