Exosomal microRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control
Abstract
Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exomiRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (n = 29, with 4.48 mean years since the last injury) compared to controls (n = 11). These miRNAs are associated with pathways of neurological disease, organismal injury and abnormalities, and psychological disease. Dysregulation of these plasma exomiRNAs in chronic mTBI may indicate that neuronal inflammation can last long after the injury and result in enduring and persistent post-injury symptoms. These findings are useful for diagnosing and treating chronic mTBIs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 24, 2021
- Source ID
- 10.3390/biomedicines10010036
Entities
People
- Carina A. Martin
- Chen Lai
- Hyung-suk Kim
- Hyunhwa Lee
- Jacob C. White
- Jessica M. Gill
- Maiko Suarez
- Rany Vorn
- Si-jung Yun
Organizations
- American Psychiatric Nurses Association
- University of Nevada, Las Vegas