Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance
Abstract
Dysregulation of pH in solid tumors is a hallmark of cancer. In recent years, the role of altered pH heterogeneity in space, between benign and aggressive tissues, between individual cancer cells, and between subcellular compartments, has been steadily elucidated. Changes in temporal pH-related processes on both fast and slow time scales, including altered kinetics of bicarbonate-CO2 exchange and its effects on pH buffering and gradual, progressive changes driven by changes in metabolism, are further implicated in phenotypic changes observed in cancers. These discoveries have been driven by advances in imaging technologies. This review provides an overview of intra- and extracellular pH alterations in time and space reflected in cancer cells, as well as the available technology to study pH spatiotemporal heterogeneity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2019
- Source ID
- 10.3390/cancers11071026
Entities
People
- David Korenchan
- Robert R Flavell
Organizations
- Foundation for the National Institutes of Health
- Tony’s Prostate Cancer Research
- United States Department of Defense
- University of California
- University of California, San Francisco