The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors
Abstract
The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously expressed in eukaryotic cells. MARCKS plays important roles in multiple cellular processes, including cell adhesion and motility, mucin secretion, exocytosis, and inflammatory response. Aberrant MARCKS signaling has been observed in the development and progression of multiple cancer types. In addition, MARCKS facilitates cancer metastasis through modulating cancer cell migration and invasion. Moreover, MARCKS contributes to treatment resistance, likely by promoting cancer stem cell renewal as well as immunosuppression. In this review, we describe MARCKS protein structure, cellular localization, and biological functions. We then discuss the role of MARCKS in cancer metastasis as well as its mechanisms of action in solid tumors. Finally, we review recent advances in targeting MARCKS as a new therapeutic strategy in cancer management.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 08, 2022
- Source ID
- 10.3390/cancers14194925
Entities
People
- Ching-hsien Chen
- Chun-Lung Chiu
- Hongjuan Zhao
- James D Brooks
- Reen Wu
Organizations
- National Institutes of Health
- United States Department of Defense