Transcriptome Meta-Analysis of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy
Abstract
Triple-negative breast cancer (TNBC) is a heterogeneous disease with varying responses to neoadjuvant chemotherapy (NAC). The identification of biomarkers to predict NAC response and inform personalized treatment strategies is essential. In this study, we conducted large-scale gene expression meta-analyses to identify genes associated with NAC response and survival outcomes. The results showed that immune, cell cycle/mitotic, and RNA splicing-related pathways were significantly associated with favorable clinical outcomes. Furthermore, we integrated and divided the gene association results from NAC response and survival outcomes into four quadrants, which provided more insights into potential NAC response mechanisms and biomarker discovery.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 07, 2023
- Source ID
- 10.3390/cancers15082194
Entities
People
- Brian D. Lehmann
- Lily Wang
- Liying Li
- Wei Zhang
- X. Steven Chen
Organizations
- California Academy of Mathematics and Science
- National Cancer Institute
- United States Department of Defense
- University of Miami
- Vanderbilt University