Regulations of Tumor Microenvironment by Prostaglandins
Abstract
Prostaglandins, the bioactive lipids generated from the metabolism of arachidonic acid through cyclooxygenases, have potent effects on many constituents of tumor microenvironments. In this review, we will describe the formation and activities of prostaglandins in the context of the tumor microenvironment. We will discuss the regulation of cancer-associated fibroblasts and immune constituents by prostaglandins and their roles in immune escapes during tumor progression. The review concludes with future perspectives on improving the efficacy of immunotherapy through repurposing non-steroid anti-inflammatory drugs and other prostaglandin modulators.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2023
- Source ID
- 10.3390/cancers15123090
Entities
People
- Daotai Nie
- Jeffrey Z. Nie
- Man-tzu Wang
Organizations
- Congressionally Directed Medical Research Programs
- Southern Illinois University
- University of Pittsburgh