Calcium-Dependent RTX Domains in the Development of Protein Hydrogels
Abstract
The RTX domains found in some pathogenic proteins encode repetitive peptide sequences that reversibly bind calcium and fold into the unique the β-roll secondary structure. Several of these domains have been studied in isolation, yielding key insights into their structure/function relationships. These domains are increasingly being used in protein engineering applications, where the calcium-induced control over structure can be exploited to gain new functions. Here we review recent advances in the use of RTX domains in the creation of calcium responsive biomaterials.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 25, 2019
- Source ID
- 10.3390/gels5010010
Entities
People
- Beyza Bulutoglu
- Scott Banta
Organizations
- Air Force Office of Scientific Research
- National Science Foundation