Wnt Signaling in Gynecologic Malignancies
Abstract
Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling, specifically Wnt/β-catenin signaling, has been found to play an essential role in many oncogenic processes in gynecologic malignancies, including tumorigenesis, metastasis, recurrence, and chemotherapy resistance. As such, the Wnt/β-catenin signaling pathway has the potential to be a target for effective treatment, improving patient outcomes. In this review, we discuss the evidence supporting the importance of the Wnt signaling pathways in the development, progression, and treatment of gynecologic malignancies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 16, 2020
- Source ID
- 10.3390/ijms21124272
Entities
People
- Alexandra Mcmellen
- Benjamin G Bitler
- Bradley R. Corr
- Elizabeth R. Woodruff
- Marisa R Moroney
Organizations
- Foundation for the National Institutes of Health
- United States Department of Defense