Offensive Behavior, Striatal Glutamate Metabolites, and Limbic–Hypothalamic–Pituitary–Adrenal Responses to Stress in Chronic Anxiety
Abstract
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 09, 2020
- Source ID
- 10.3390/ijms21207440
Entities
People
- Alexey P. Sarapultsev
- Anna S. Khotskina
- Enrico Ullmann
- Evgenii Zavjalov
- Galina Koncevaya
- Georgios P. Chrousos
- Igor Kritsky
- Julio Licinio
- Jörg M. Fegert
- Ma-li Wong
- Maria V. Komelkova
- Maryia Vasilyeva
- Maxim S. Lapshin
- Mikhail Moshkin
- Nikita Khotskin
- Oleg Shevelev
- Olga Cherkasova
- Olga Tseilikman
- Rachel Yehuda
- Roman Ibragimov
- Seth W. Perry
- Stefan R. Bornstein
- Vadim Tseilikman
Organizations
- Russian Science Foundation
- United States Department of Defense
- United States Department of Veterans Affairs