The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases
Abstract
The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 13, 2021
- Source ID
- 10.3390/ijms22020721
Entities
People
- Rachel L. Redfern
- Vinay K. Aakalu
- Youssof Eshac
Organizations
- National Eye Institute
- Research to Prevent Blindness
- United States Department of Defense
- United States Department of Veterans Affairs