The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
Abstract
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and degenerative diseases. Recently developed cell and drug-based immunomodulatory strategies are highlighted. An improved understanding of the immune response to injured and diseased skeletal muscle will be essential for the development of therapeutic strategies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 23, 2021
- Source ID
- 10.3390/ijms22063265
Entities
People
- Genevieve Hilliard
- Koyal Garg
- Natalia Ziemkiewicz
- Nicholas A Pullen
Organizations
- National Institute of General Medical Sciences
- United States Department of Defense