The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling
Abstract
Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in homeostasis and disease are becoming increasingly apparent. Recently, the cardiac lymphatic vasculature in zebrafish has been described and its role in supporting the potent regenerative response of zebrafish heart tissue investigated. In this review, we discuss these findings in the wider context of lymphatic development, evolution and the promise of this system to open new therapeutic avenues to treat myocardial infarction and other cardiopathologies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 19, 2021
- Source ID
- 10.3390/jcdd8020021
Entities
People
- Caroline A. Pearson
- Ching-ling Lien
- Michael Rm Harrison
- Stanislao Travisano
- Xidi Feng
Organizations
- National Institutes of Health
- Tobacco-Related Disease Research Program
- United States Department of Defense