A Systems Biology Approach for Addressing Cisplatin Resistance in Non-Small Cell Lung Cancer
Abstract
Translational research in medicine, defined as the transfer of knowledge and discovery from the basic sciences to the clinic, is typically achieved through interactions between members across scientific disciplines to overcome the traditional silos within the community. Thus, translational medicine underscores ‘Team Medicine’, the partnership between basic science researchers and clinicians focused on addressing a specific goal in medicine. Here, we highlight this concept from a City of Hope perspective. Using cisplatin resistance in non-small cell lung cancer (NSCLC) as a paradigm, we describe how basic research scientists, clinical research scientists, and medical oncologists, in true ‘Team Science’ spirit, addressed cisplatin resistance in NSCLC and identified a previously approved compound that is able to alleviate cisplatin resistance in NSCLC. Furthermore, we discuss how a ‘Team Medicine’ approach can help to elucidate the mechanisms of innate and acquired resistance in NSCLC and develop alternative strategies to overcome drug resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 11, 2023
- Source ID
- 10.3390/jcm12020599
Entities
People
- Arin Nam
- Atish Mohanty
- Bolot Mambetsariev
- Erminia Massarelli
- Evan Pisick
- Jyoti Malhotra
- Linlin Guo
- Prakash Kulkarni
- Ravi Salgia
- Sandeep Mittan
- Shanmuga Subbiah
- Sharad S Singhal
- Sravani Ramisetty
- Supriyo Bhattacharya
- Swapnil Rajurkar
- Tamara Mirzapoiazova